Understanding infections in diabetic wounds caused by Group B Streptococcus
Official title: Determinants of polymicrobial diabetic wound infections
Funded at University of Colorado Denver · NIH-10876341 · Data updated 2026-11-12
This study is looking at how a common bacteria called Group B Streptococcus affects infections in wounds for people with diabetes, using mice to help find better ways to treat these wounds.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI171853-02 |
| Project ID | NIH-10876341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are experiencing chronic wounds or infections.
✕Less likely to help
Patients without diabetes or those not suffering from chronic wounds may not benefit from this research.
What this research studies
This research investigates how Group B Streptococcus (GBS), a common bacterium, contributes to infections in diabetic wounds. It focuses on understanding the behavior of GBS in a diabetic environment using a mouse model that mimics human diabetes. The study aims to identify the genetic factors that make GBS more virulent in these wounds, which could lead to better treatment strategies for diabetic patients suffering from chronic wounds. By analyzing the interactions between GBS and the immune response in diabetic wounds, the research seeks to uncover new insights into infection management.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic wound infections, potentially reducing the need for amputations and enhancing healing.
How similar studies have gone: Previous research has shown success in understanding bacterial infections in diabetic wounds, but this specific focus on GBS is novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Doran, Kelly S — University of Colorado Denver
- Study coordinator: Doran, Kelly S
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How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.