Understanding infection risks in young children
Official title: Inflammatory subtypes and multi-omic determinants of early life infection risk
Funded at Brigham and Women's Hospital · NIH-10947656 · Data updated 2026-11-12
This study is looking at how certain biological factors might make young children more likely to get respiratory infections, and it’s for families with kids under five who want to help us understand how genes and the environment affect their little ones' health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $177,721 |
| NIH project number | 1K01HL175261-01 |
| Project ID | NIH-10947656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under the age of five, particularly those with a history of respiratory infections.
✕Less likely to help
Patients who are older than five years or do not have a history of respiratory infections may not benefit from this research.
What this research studies
This research investigates the biological factors that contribute to respiratory infection risks in children under five years old. By analyzing data from a cohort of children, the study aims to identify distinct inflammatory profiles that may predict susceptibility to infections. The approach combines advanced techniques in biochemistry and immunology to explore how genetic and environmental factors interact in early life. Participants will be monitored over several years to gather comprehensive data on their health and infection experiences.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing respiratory infections in young children.
How similar studies have gone: Previous research has shown promise in using multi-omic approaches to understand disease susceptibility, indicating potential for success in this novel investigation.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Prince, Nicole — Brigham and Women's Hospital
- Study coordinator: Prince, Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.