Understanding immunity to dengue and Zika viruses in different populations
Flavivirus immunity in endemic and non-endemic human cohorts
This study is looking at how people's immune systems react to dengue and Zika viruses in places where these viruses are common compared to places where they aren't, to help improve vaccines and treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11019785 on NIH RePORTER |
What this research studies
This research investigates how the immune response to dengue and Zika viruses varies between populations living in areas where these viruses are common and those where they are not. By studying blood samples from individuals in both endemic and non-endemic regions, the researchers aim to understand how antibodies develop and change over time in response to these viruses. The study will analyze the effectiveness of these antibodies in providing protection against future infections, which is crucial for developing effective vaccines and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to dengue or Zika viruses, particularly those living in endemic regions.
Not a fit: Patients who have never been exposed to dengue or Zika viruses or those living in areas where these viruses are not present may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and therapies for dengue and Zika virus infections, ultimately reducing disease burden.
How similar studies have performed: Previous research has shown varying immune responses to flaviviruses in different populations, indicating that this area of study is both relevant and necessary for advancing our understanding of viral immunity.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Messer, William — Oregon Health & Science University
- Study coordinator: Messer, William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.