Understanding immune system issues in pregnant women with HIV and malaria
Mechanisms of innate immune dysfunction in SIV/malaria co-infection in pregnancy
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-10890719
This study is looking at how having both HIV and malaria affects the immune system of pregnant women, using pregnant monkeys to learn more about the problems that can arise during pregnancy, with the hope of finding better treatments to help keep both moms and their babies healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10890719 on ClinicalTrials.gov |
What this research studies
This research investigates how co-infection with HIV and malaria affects the immune system in pregnant women. By studying pregnant rhesus macaques infected with both diseases, the researchers aim to uncover the mechanisms that lead to complications during pregnancy. The focus is on understanding the role of specific immune cells, such as neutrophils and innate lymphoid cells, in the development of these complications. The ultimate goal is to identify new treatment options that can improve health outcomes for both mothers and their babies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who are co-infected with HIV and malaria.
Not a fit: Patients who are not pregnant or do not have co-infection with HIV and malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce health risks for pregnant women living with HIV and malaria.
How similar studies have performed: Previous research has shown that understanding immune responses in co-infections can lead to improved treatment strategies, indicating potential success for this approach.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MANUZAK, JENNIFER — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: MANUZAK, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus