Understanding immune system issues in people with Down syndrome
Dissecting T and B cell dysregulation in people with Down syndrome
This study is looking at how the immune system works in people with Down syndrome, especially focusing on important immune cells, to better understand how their immune responses to vaccines and autoimmune conditions might be affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11167301 on NIH RePORTER |
What this research studies
This research investigates how the immune system functions in individuals with Down syndrome (DS), particularly focusing on T and B cells, which are crucial for immune responses. The study aims to identify the mechanisms that lead to immune dysregulation in DS, including both intrinsic factors within the cells and external factors from the environment. By assembling a large cohort of individuals with DS, the research will perform detailed analyses to understand how these immune features affect responses to vaccines and the presence of autoimmune conditions. This comprehensive approach seeks to enhance our understanding of immune aging and response in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Down syndrome across various age groups.
Not a fit: Patients without Down syndrome or those with unrelated immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine responses and better management of autoimmune conditions in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in similar populations, indicating that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Khor, Bernard — Benaroya Research Inst at Virginia Mason
- Study coordinator: Khor, Bernard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.