Understanding immune signaling networks in individual cells
Official title: Comprehensive characterization of immune signaling networks in single-cells by joint quantification of proteins, protein complexes and mRNA
Funded at University of Chicago · NIH-11010774 · Data updated 2026-11-12
This study is exploring a new way to look at proteins in single immune cells to better understand how they work and respond to different challenges, which could help improve treatments for various conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 17, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $652,880 |
| NIH project number | 5R01AI175321-03 |
| Project ID | NIH-11010774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune disorders or those undergoing treatments that affect immune function.
✕Less likely to help
Patients with stable, non-autoimmune conditions or those not affected by immune signaling pathways may not benefit from this research.
What this research studies
This research focuses on developing a new technology to measure proteins and their complexes in single immune cells, which is crucial for understanding how these cells function and respond to various stimuli. By using a method called Intracellular Proximity-Sequencing (iProx-seq), researchers aim to simultaneously quantify proteins, protein complexes, and mRNA in thousands of individual cells. This approach will help uncover new insights into immune development, signaling pathways, and potential drug resistance mechanisms, ultimately enhancing our understanding of immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and better strategies for managing immune-related conditions.
How similar studies have gone: Other research has shown promise in using single-cell analysis to understand immune responses, making this approach both innovative and grounded in prior success.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Tay, Savas — University of Chicago
- Study coordinator: Tay, Savas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.