Understanding immune signaling in blood cell formation and disorders
Official title: Decoding innate immune signaling in normal and myelodysplastic hematopoiesis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11002726 · Data updated 2026-11-12
This study is looking at how the body's immune system affects the production of blood cells in older adults with myelodysplastic syndromes (MDS), with the goal of finding new treatments to help manage this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $981,728 |
| NIH project number | 5R35HL166430-03 |
| Project ID | NIH-11002726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over 60 years of age, who are diagnosed with myelodysplastic syndromes.
✕Less likely to help
Patients with other types of blood disorders that are not related to myelodysplastic syndromes may not benefit from this research.
What this research studies
This research investigates how innate immune signaling affects blood cell formation, particularly in patients with myelodysplastic syndromes (MDS), which are common in older adults. The team aims to uncover the genetic and cellular factors that contribute to MDS and explore how immune pathways are involved in both normal and abnormal blood cell development. By identifying these mechanisms, they hope to develop new drug therapies that can effectively treat MDS. This research is crucial as it addresses a significant gap in understanding a condition that currently has no effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to new and effective treatments for patients suffering from myelodysplastic syndromes.
How similar studies have gone: Other research has shown promise in targeting immune pathways for blood disorders, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Starczynowski, Daniel — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Starczynowski, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.