Understanding immune responses to tuberculosis in infants exposed to HIV
Immune correlates of LTBI in HIV-exposed infants
This study is looking at how latent tuberculosis infection (LTBI) impacts babies who are exposed to HIV, by checking their immune responses through blood samples from both moms and babies, to help find better ways to keep these little ones safe from tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10747368 on NIH RePORTER |
What this research studies
This research investigates how latent tuberculosis infection (LTBI) affects infants who are exposed to HIV, focusing on their immune responses. By analyzing maternal and infant blood samples, the study aims to uncover the relationship between maternal health, HIV exposure, and the risk of developing active tuberculosis in infants. The research utilizes advanced techniques like flow cytometry to assess immune cell characteristics and responses. The goal is to improve understanding of how to protect these vulnerable infants from tuberculosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants who are exposed to HIV, particularly those born to HIV-positive mothers.
Not a fit: Patients who are not exposed to HIV or who are older than infants may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and vaccines for tuberculosis in infants exposed to HIV.
How similar studies have performed: Previous research has shown promise in understanding immune responses in similar populations, but this specific approach is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pahwa, Savita — University of Miami School of Medicine
- Study coordinator: Pahwa, Savita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.