Understanding immune responses to malaria vaccination
Collective Responses to Malaria Vaccination
This study is looking at how the immune system reacts to a malaria vaccine made from weakened parasites, and it's for people who want to help researchers understand what makes the vaccine work better for those who have and haven't had malaria before.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11016925 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to a malaria vaccine made from weakened malaria parasites. By analyzing blood samples from individuals who have received the vaccine, researchers aim to identify specific immune responses that lead to protection against malaria. The study will use advanced techniques to track both the cellular and antibody responses over time, focusing on how these responses differ between people who have never had malaria and those who have. The goal is to uncover the key immune characteristics that contribute to effective vaccination.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are either malaria-naïve or have experienced malaria and are willing to participate in vaccination trials.
Not a fit: Patients who are not interested in malaria vaccination or those with severe immune system disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria vaccines that provide long-lasting immunity.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to other vaccines, suggesting that this approach could yield valuable insights for malaria vaccination.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Stuart, Kenneth D — Seattle Children's Hospital
- Study coordinator: Stuart, Kenneth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.