Understanding immune responses to Klebsiella infections for vaccine development
Protective immunity elicited by distinct polysaccharide antigens of classical and hypervirulent Klebsiella
This study is looking at how our immune system fights off Klebsiella pneumoniae, a germ that can cause serious infections, to help create better vaccines that protect against it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10914896 on NIH RePORTER |
What this research studies
This research focuses on how the immune system responds to Klebsiella pneumoniae, a bacterium that causes serious infections like pneumonia and urinary tract infections. The team is investigating specific polysaccharide antigens of the bacteria to develop effective vaccines. They are using advanced techniques to create bioconjugate vaccines that combine these antigens with carrier proteins to enhance immune response. The ultimate goal is to provide better protection against both classical and hypervirulent strains of Klebsiella.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for Klebsiella infections, such as hospitalized patients or those with weakened immune systems.
Not a fit: Patients who are not at risk for Klebsiella infections or those with existing immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines that protect patients from serious Klebsiella infections.
How similar studies have performed: Previous research has shown promise in developing vaccines targeting similar bacterial infections, indicating potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Rosen, David a. — Washington University
- Study coordinator: Rosen, David a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.