Understanding immune responses to influenza for better vaccine development
Official title: Influenza Modeling of Correlates of Protection for Optimal Immune Dynamics and Evolution.
Funded at Emory University · NIH-11017518 · Data updated 2026-11-12
This study is looking at how our immune system reacts to the flu and flu shots to find ways to make vaccines work better for everyone, especially those with different health conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 24, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,171,832 |
| NIH project number | 1U01AI187057-01 |
| Project ID | NIH-11017518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been infected with influenza or have received influenza vaccinations, particularly those with diverse health backgrounds.
✕Less likely to help
Patients who have never been infected with influenza or have not received any vaccinations may not benefit from this research.
What this research studies
This research investigates how the immune system responds to influenza infections and vaccinations to identify key markers that can improve vaccine effectiveness. By analyzing data from individuals infected with influenza, including those with varying health conditions, the study aims to uncover the molecular mechanisms that lead to optimal protection against the virus. The researchers will utilize advanced machine learning techniques to model these immune responses and identify early indicators of successful immunity. This approach could lead to more effective vaccines tailored to enhance immune protection.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective influenza vaccines that provide better protection against the virus.
How similar studies have gone: Previous research has shown success in using similar approaches to understand immune responses, particularly in the context of other viral infections.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Medina Silva, Rafael a. — Emory University
- Study coordinator: Medina Silva, Rafael a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.