Understanding immune responses to HIV vaccine candidates
Project 2: Immune Response Analysis
['FUNDING_P01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11312616
Scientists are using detailed lab tests to learn how adults' immune systems respond to new HIV vaccine pieces so future vaccines can protect more people.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11312616 on ClinicalTrials.gov |
What this research studies
If I were part of this effort, researchers would use advanced 'multi-omics' tests to examine many layers of my immune response after receiving experimental HIV vaccine components. They will isolate antibodies made in HIV‑negative humans to see whether the vaccine parts trigger the rare broadly neutralizing antibodies thought to block many HIV strains. Teams will combine genetic, structural, and protein-level analyses to spot which vaccine designs work and which regions need improvement. The project aims to pull as much information as possible from each immunization to guide better combinations and delivery of vaccine components.
Who could benefit from this research
Good fit: Ideal participants are HIV‑negative adults (typically 21 years or older) who can receive candidate immunogens and provide blood samples for detailed laboratory analysis.
Not a fit: People already living with HIV or those needing immediate HIV treatment are unlikely to gain direct clinical benefit from this vaccine-development project.
Why it matters
Potential benefit: If successful, this work could point the way to HIV vaccines that reliably trigger broad protective antibodies and help prevent infection.
How similar studies have performed: Researchers have previously isolated human antibodies and applied multi-omics in early HIV vaccine research, but turning those insights into a proven, protective HIV vaccine remains unproven.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRINEY, BRYAN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: BRINEY, BRYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus