Understanding immune responses to factor VIII in hemophilia A
Official title: Defining the Innate Immune Cell Profile of Factor VIII Immunity
Funded at Stanford University · NIH-11062131 · Data updated 2026-11-12
This study is looking at how the immune system responds to a key protein used in treating hemophilia A, with the goal of finding ways to stop the body from creating antibodies that make the treatment less effective, so patients can have better outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 18, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $395,314 |
| NIH project number | 1R00HL177822-01 |
| Project ID | NIH-11062131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hemophilia A who have developed inhibitors against factor VIII or are at risk of developing them.
✕Less likely to help
Patients without hemophilia A or those who do not have issues with factor VIII treatment may not benefit from this research.
What this research studies
This research investigates how the immune system reacts to factor VIII, a crucial protein for blood clotting, in patients with hemophilia A. It aims to identify the immune cells involved and the mechanisms that lead to the development of inhibitors, which are antibodies that neutralize the effectiveness of factor VIII treatments. By understanding these processes, the research seeks to develop new therapies that can prevent these inhibitors from forming and improve treatment outcomes for patients. The approach includes analyzing immune cell profiles and early immunologic events related to factor VIII immunity.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for hemophilia A, reducing complications and improving the quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding immune responses in hemophilia, but this specific approach to defining immune cell profiles and developing targeted therapies is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Batsuli, Glaivy — Stanford University
- Study coordinator: Batsuli, Glaivy
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to predict CAR-T patient response and guide safer, smarter cell design
A Stanford team is building AI tools that use patient and CAR-T cell data to predict how well a CAR-T therapy will work and what design changes might boost effectiveness and safety for people with cancer.
-
Community-driven model to reduce overdose deaths through smarter resource use
A Stanford-led project uses a data-driven model to help counties pick the best ways to prevent opioid and stimulant overdoses and save lives.
-
Center for Dissemination and Implementation at Stanford: Research Core
A Stanford-based program is advancing how evidence-based addiction treatments are implemented across settings to help people with substance use disorders receive better care.
-
Center for Dissemination and Implementation At Stanford (C-DIAS)
A center-based program at Stanford aims to speed people who need addiction treatments to get evidence-based care.
-
Mitochondrial structure and neuron health in Alzheimer's and ALS
This grant studies how mitochondrial cristae structure in neurons is controlled and how its disruption may contribute to diseases like Alzheimer's and ALS.
-
Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.