Understanding immune responses to congenital cytomegalovirus during pregnancy
Immune defense of cCMV at the maternal-fetal interface
['FUNDING_P01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10874238
This study is looking at how a mother’s immune system can help protect her baby from congenital cytomegalovirus (cCMV) during pregnancy, with the goal of finding ways to create a vaccine that could keep both moms and babies safe.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10874238 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system interacts with congenital cytomegalovirus (cCMV) at the maternal-fetal interface, which is crucial for preventing transmission of the virus from mother to fetus. Using a nonhuman primate model, the study aims to identify immune responses that could lead to effective vaccine development. Researchers will analyze placental tissues and immune interactions to understand how to balance protective immunity and avoid harmful immune responses. The findings could provide insights into developing a maternal vaccine against cCMV.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women, particularly those in their first or second trimester, who may be at risk of cCMV infection.
Not a fit: Patients who are not pregnant or those who have already been infected with cCMV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that protects newborns from hearing loss and neurological issues caused by cCMV.
How similar studies have performed: Other research has shown promise in understanding immune responses to viral infections, but this specific approach to cCMV at the maternal-fetal interface is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAUR, AMITINDER — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: KAUR, AMITINDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.