Understanding immune responses to congenital and postnatal cytomegalovirus infections
Official title: Adaptive Immune Responses to Congenital and Postnatal Cytomegalovirus Infection
Funded at Research Inst Nationwide Children's Hosp · NIH-11073645 · Data updated 2026-11-12
This study is looking at how a virus called congenital cytomegalovirus (cCMV) affects the immune system in babies, especially compared to those who get the virus after birth, to help find better ways to support their development and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | May 2, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $598,664 |
| NIH project number | 1R01AI181261-01A1 |
| Project ID | NIH-11073645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants diagnosed with congenital cytomegalovirus infection and those who have experienced postnatal CMV infection.
✕Less likely to help
Patients who are older than 11 years or those without any form of cytomegalovirus infection may not benefit from this research.
What this research studies
This research investigates how congenital cytomegalovirus (cCMV) infection affects the immune responses in infants compared to those who acquire the virus postnatally. The study aims to identify the differences in T cell responses, which may lead to neurodevelopmental issues in infants with cCMV. By comparing immune responses in a large group of infants with cCMV to those with postnatal infections, the researchers hope to uncover mechanisms that could improve treatment and outcomes for affected children.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of immune responses in infants, potentially reducing the risk of neurodevelopmental impairments associated with cCMV.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to viral infections, making this approach both relevant and potentially impactful.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Shimamura, Masako — Research Inst Nationwide Children's Hosp
- Study coordinator: Shimamura, Masako
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.