Understanding immune responses to Chlamydia infections using mouse models
Developing mouse models to study circulating memory to Chlamydia infection
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10738810
This study is looking at how the immune system, especially certain immune cells called CD4 T cells, helps fight off Chlamydia infections in women, using mouse models to learn more about how these cells work and how they could help in creating better vaccines.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10738810 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system responds to Chlamydia infections, particularly focusing on the role of specific immune cells called CD4 T cells in the female reproductive tract. By developing mouse models that mimic natural infection routes, the researchers aim to visualize and understand how these immune cells help clear the infection. The study will explore how memory immune cells are recruited and how they contribute to fighting the infection, which is crucial for developing effective vaccines against Chlamydia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of Chlamydia infections, particularly women of reproductive age.
Not a fit: Patients who are not at risk for Chlamydia infections or those who have already been vaccinated against it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that prevents Chlamydia infections, reducing the incidence of related health issues such as infertility and blindness.
How similar studies have performed: Previous research has shown promise in understanding immune responses to infections, but this specific approach using mouse models for Chlamydia is relatively novel.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCSORLEY, STEPHEN J — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: MCSORLEY, STEPHEN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: United States Centers for Disease Control and Prevention, Centers for Disease Control and Prevention (U.S.), Chlamydial Infection, chlamydial disease, Chlamydia Infections