Understanding immune responses to Chlamydia infections using mouse models
Official title: Developing mouse models to study circulating memory to Chlamydia infection
Funded at University of California at Davis · NIH-10738810 · Data updated 2026-11-12
This study is looking at how the immune system, especially certain immune cells called CD4 T cells, helps fight off Chlamydia infections in women, using mouse models to learn more about how these cells work and how they could help in creating better vaccines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | November 10, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $190,107 |
| NIH project number | 5R21AI169123-02 |
| Project ID | NIH-10738810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of Chlamydia infections, particularly women of reproductive age.
✕Less likely to help
Patients who are not at risk for Chlamydia infections or those who have already been vaccinated against it may not benefit from this research.
What this research studies
This research investigates how the immune system responds to Chlamydia infections, particularly focusing on the role of specific immune cells called CD4 T cells in the female reproductive tract. By developing mouse models that mimic natural infection routes, the researchers aim to visualize and understand how these immune cells help clear the infection. The study will explore how memory immune cells are recruited and how they contribute to fighting the infection, which is crucial for developing effective vaccines against Chlamydia.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that prevents Chlamydia infections, reducing the incidence of related health issues such as infertility and blindness.
How similar studies have gone: Previous research has shown promise in understanding immune responses to infections, but this specific approach using mouse models for Chlamydia is relatively novel.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Mcsorley, Stephen J — University of California at Davis
- Study coordinator: Mcsorley, Stephen J
Related research
Other NIH-funded projects on the same topics.
-
UC Davis IGA Innovation Center
A research center at UC Davis will study gene-edited livestock to improve animal health, safety, and policy through sharing genetic data and findings about genome edits in cattle, pigs, sheep, and goats.
-
Administrative Core of an equitable breast cancer screening program
A national program headed from UC Davis is coordinating several research efforts to improve how breast cancer screening is done in community settings.
-
The role of novelty and surprise in learning for people with Alzheimer’s disease
A study explores how surprising events affect memory and learning in people related to Alzheimer’s disease, using everyday tasks to see how the brain remembers new information.
-
Understanding how distraction affects students and how to measure it better
This grant studies why distracted students, including those with ADHD, struggle in real-life learning and tests a clearer way to measure distraction in everyday settings.
-
California Partnership for Personalized Nutrition
A California clinical center is testing personalized dietary approaches to improve blood sugar and health for adults with diabetes by using big data and AI to tailor meals.
-
Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.