Understanding immune responses to Aspergillus in patients with low neutrophil counts
Adaptive immunity to Aspergillus during neutropenia
This study is looking at how the immune system fights off Aspergillus infections in people with neutropenia, a condition where the body has low levels of infection-fighting cells, to find ways to improve treatments for those affected by serious lung infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10949011 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to Aspergillus infections in individuals with neutropenia, a condition characterized by low levels of neutrophils, which are crucial for fighting infections. The study focuses on the role of neutrophils in shaping adaptive immunity, particularly the production of IL-17A by CD4+ T cells, which may help protect against future infections. By examining the immune responses in animal models, the researchers aim to uncover mechanisms that could lead to better treatments for patients suffering from invasive pulmonary aspergillosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neutropenia or neutrophil defects who are at risk for invasive pulmonary aspergillosis.
Not a fit: Patients with normal neutrophil counts or those not at risk for Aspergillus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating life-threatening Aspergillus infections in vulnerable patients.
How similar studies have performed: Previous research has shown that understanding immune responses in similar contexts can lead to significant advancements in treatment options, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cagnina, Rebecca Elaine — Brigham and Women's Hospital
- Study coordinator: Cagnina, Rebecca Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.