Understanding immune responses that lead to blood transfusion complications
Examining Immune Circuits Responsible for Anamnestic RBC Alloimmunization
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10876330
This study is looking at how your immune system responds to blood transfusions, especially how it can create antibodies that might cause problems later on, and it's aimed at finding ways to keep you safe if you need a transfusion.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10876330 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system reacts to blood transfusions, particularly focusing on the formation of alloantibodies that can occur after a patient has previously been exposed to certain blood antigens. The study aims to identify specific immune pathways that trigger these responses, which can lead to serious complications like delayed hemolytic transfusion reactions. By examining the roles of different immune cells, such as B cells and T cells, the researchers hope to uncover new strategies to prevent these dangerous reactions in patients who require blood transfusions.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have a history of blood transfusions and are at risk for developing alloantibodies.
Not a fit: Patients who have never received a blood transfusion or do not have a history of alloimmunization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and outcomes for patients receiving blood transfusions by preventing potentially fatal reactions.
How similar studies have performed: Previous research has shown promise in understanding immune responses related to blood transfusions, but this specific approach targeting anamnestic responses is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STOWELL, SEAN R — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: STOWELL, SEAN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.