Understanding immune responses in transplant patients
Official title: Immunosurveillance and Immunopathology Core
Funded at University of Minnesota · NIH-11063822 · Data updated 2026-11-12
This study is looking at how the immune system changes in people who have received organ transplants, to see how different treatments can help their bodies accept the new organs better and improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 20, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $472,311 |
| NIH project number | 5U19AI174966-03 |
| Project ID | NIH-11063822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received organ transplants and are undergoing evaluation for immune response.
✕Less likely to help
Patients who have not undergone organ transplantation or those with autoimmune diseases unrelated to transplant procedures may not benefit from this research.
What this research studies
This research focuses on analyzing immune changes in patients who have undergone organ transplants. By studying blood and tissue samples, the project aims to understand how different tolerance regimens affect the immune system's response to transplanted organs. The research employs advanced assays and bioinformatics techniques to ensure consistent and accurate results across multiple studies. Patients' immune responses will be closely monitored to identify potential improvements in transplant acceptance and overall health.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for achieving transplant tolerance, reducing the need for lifelong immunosuppressive therapy.
How similar studies have gone: Previous research has shown promise in understanding immune responses in transplant patients, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Ramachandran, Sabarinathan — University of Minnesota
- Study coordinator: Ramachandran, Sabarinathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.