Understanding immune responses in Thai children with HIV after early treatment
Official title: Persistence of HIV-specific CD8+ T cell responses after long-term ART in early treated Thai children
Funded at Oregon Health & Science University · NIH-11132916 · Data updated 2026-11-12
This study is looking at how the immune systems of Thai children who started HIV treatment early respond over time, especially focusing on certain immune cells, to help find better ways to manage HIV in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $197,192 |
| NIH project number | 5R21AI181636-02 |
| Project ID | NIH-11132916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Thai children who were diagnosed with HIV and started ART before six months of age.
✕Less likely to help
Patients who were diagnosed with HIV after six months of age or those who have not received ART may not benefit from this research.
What this research studies
This research investigates how the immune system of Thai children who were treated early for HIV responds over time, particularly focusing on the persistence of specific immune cells known as CD8+ T cells. By following children who started antiretroviral therapy (ART) before six months of age, the study aims to understand how these immune responses differ from those in adults and how they change over a period of 6 to 10 years on ART. The goal is to gather insights that could lead to new immunotherapies that allow for better control of HIV without the need for ongoing ART. Patients will be monitored through blood samples and immune assays to assess the functionality of their immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for children with HIV, potentially allowing for better immune control of the virus without continuous medication.
How similar studies have gone: Previous studies have shown promising results in understanding immune responses in children with HIV, but this specific approach focusing on long-term ART effects in a pediatric population is relatively novel.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mitchell, Julie — Oregon Health & Science University
- Study coordinator: Mitchell, Julie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.