Understanding immune responses in severe dengue infections in children
Immune responses associated with severe disease in patients with primary dengue infection
This study is looking at how children's immune systems react to dengue infections, especially to understand the differences between mild and severe cases, which could help improve treatments and vaccines for kids under 11.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11000009 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to primary dengue infections, particularly in children under 11 years old. It aims to identify differences in immune responses between severe primary and secondary dengue infections, focusing on the roles of specific immune cells and antibodies. By conducting comprehensive studies in India, the research seeks to fill knowledge gaps regarding the pathogenesis of severe dengue, which is crucial as the disease spreads to new areas. The findings could lead to improved clinical management and vaccine development.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are experiencing primary dengue infections.
Not a fit: Patients with secondary dengue infections or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies and vaccines for dengue, particularly for children experiencing severe disease.
How similar studies have performed: Previous research has shown significant insights into secondary dengue infections, but this investigation into primary infections is relatively novel and untested.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kaja, Murali Krishna — Emory University
- Study coordinator: Kaja, Murali Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.