Understanding immune responses in sepsis patients
Stratifying Patient Immune Endotypes in Sepsis (SPIES Study)
This study is looking at how the immune systems of people who have survived sepsis work, to help find better ways to understand their health and create more personalized treatments for any ongoing health problems they might have.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10876465 on NIH RePORTER |
What this research studies
This research investigates how to better classify and understand the immune responses of patients who have survived sepsis. By focusing on the immune system's function, the study aims to identify specific immune endotypes and measure immune suppression in these patients. The approach includes assessing T cell and monocyte activity through specialized tests, which may provide insights into their long-term health outcomes. This could lead to more personalized treatments for sepsis survivors who often face chronic health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently survived sepsis and are experiencing ongoing health challenges.
Not a fit: Patients who have not experienced sepsis or those with acute, non-sepsis related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for sepsis survivors, enhancing their recovery and quality of life.
How similar studies have performed: Previous research has shown promise in understanding immune responses in sepsis, but this approach aims to refine and improve upon those methods.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Maile, Robert — University of Florida
- Study coordinator: Maile, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.