Understanding immune responses in plants using GBPL proteins
Official title: Immune control by GBPL proteins in Arabidopsis
Funded at Ohio State University · NIH-11132943 · Data updated 2026-11-12
This study is looking at how certain proteins in plants, called GBPL proteins, help them fight off harmful invaders, and it's for anyone interested in how plants protect themselves from threats.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $373,953 |
| NIH project number | 5R35GM154863-02 |
| Project ID | NIH-11132943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are scientists and agricultural researchers interested in plant biology and disease resistance.
✕Less likely to help
Patients or individuals not involved in plant research or agriculture will likely not benefit from this research.
What this research studies
This research investigates how a specific group of proteins, known as Guanylate binding protein-like (GBPL) proteins, helps plants like Arabidopsis thaliana defend against harmful invaders. By using advanced techniques such as targeted mutagenesis and imaging, the researchers aim to uncover the mechanisms by which these proteins regulate immune responses and maintain balance in plant defense systems. The study focuses on two GBPL proteins, GBPL1 and GBPL2, to understand their roles in sensing threats and triggering immune reactions.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing plant immunity, which may benefit agricultural practices and food security.
How similar studies have gone: While the specific approach of studying GBPL proteins in plants is novel, similar research on plant immune responses has shown promising results in the past.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Huang, Shuai — Ohio State University
- Study coordinator: Huang, Shuai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.