Understanding immune responses in osteoarthritis pain and progression
Official title: BCCMA: Targeting Osteoarthritis Pain and Progression: Proteomics, RNASeq & Immunostaining to elucidate the immune pathotypes of OA
Funded at Veterans Admin Palo Alto Health Care Sys · NIH-11043372 · Data updated 2026-11-12
This study is looking at how your immune system affects pain and the progression of osteoarthritis, using samples from people at different stages of the condition, to help create personalized treatments that can ease your pain and slow down the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX002523-03 |
| Project ID | NIH-11043372 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with osteoarthritis, particularly those experiencing varying levels of pain and disease progression.
✕Less likely to help
Patients with osteoarthritis who do not have significant immune involvement or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates how different immune responses contribute to pain and progression in osteoarthritis (OA). By analyzing biospecimens from patients with early and late-stage OA, the study aims to identify specific immune pathotypes that influence the disease's development. The approach includes advanced techniques like proteomics, RNA sequencing, and immunostaining to uncover the cellular and molecular mechanisms at play. Ultimately, the goal is to develop targeted treatments that can alleviate pain and slow down OA progression based on individual immune profiles.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies that significantly reduce osteoarthritis pain and slow disease progression.
How similar studies have gone: Previous studies have shown promise in understanding immune mechanisms in osteoarthritis, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
-
Veterans Admin Palo Alto Health Care Sys
Palo Alto, United States Active
Researchers
- Principal investigator: Robinson, William H — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Robinson, William H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.