Understanding immune responses in organ transplant patients
Project 1: Evolution and Durability of allo(auto)immune B cell responses in organ transplant recipients
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11075872
This study looks at how your body's B cells, which make antibodies, react to kidney transplants, especially when they accidentally attack the new organ, and it aims to find better ways to help your body accept the transplant and reduce complications.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11075872 on ClinicalTrials.gov |
What this research studies
This research investigates how B cells, which produce antibodies, respond to organ transplants, particularly focusing on kidney transplants. It aims to understand the evolution and durability of these immune responses, especially when they mistakenly target the donor's proteins, leading to rejection of the transplant. By studying the mechanisms behind these responses, the research seeks to identify ways to improve transplant outcomes and manage complications related to antibody-mediated rejection. Patients may be monitored for their immune responses over time to gather valuable data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and may be experiencing or at risk for antibody-mediated rejection.
Not a fit: Patients who have not undergone organ transplantation or those with other unrelated autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection in transplant patients.
How similar studies have performed: Previous studies have shown that understanding B cell responses can lead to better management of transplant rejection, indicating that this approach has potential for success.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUND, FRANCES E. — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: LUND, FRANCES E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.