Understanding Immune Responses in Infectious Diseases Using 3D Protein Information
Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease
This project helps us understand how our immune system responds to infections like HIV by looking closely at the detailed 3D structures of proteins.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11136334 on NIH RePORTER |
What this research studies
Our bodies have complex immune systems that fight off infections, but sometimes we don't fully understand how they work at a molecular level. This project uses a new way to combine information about our genes with detailed 3D pictures of proteins, which are the building blocks of our cells. By looking at these protein networks in three dimensions, we can get a clearer picture of how the immune system reacts to diseases. This deeper understanding helps us identify the specific molecular changes that drive how infectious diseases affect us.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the immune system in infectious diseases, particularly those like HIV, and does not involve direct patient recruitment at this stage.
Not a fit: Patients not affected by infectious diseases or those seeking immediate clinical interventions would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify key immune responses and develop better treatments or vaccines for infectious diseases.
How similar studies have performed: This project proposes a novel framework for integrating genomic data with 3D protein networks, building upon existing knowledge but offering a new approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Das, Jishnu — University of Pittsburgh at Pittsburgh
- Study coordinator: Das, Jishnu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.