Understanding immune responses in drug allergies
Official title: Interrogating Clonal Repertoire in Drug Hypersensitivity Reactions
Funded at Brigham and Women's Hospital · NIH-10983333 · Data updated 2026-11-12
This study is looking into skin reactions caused by certain medications to find out which immune cells are involved and to create a simple test that can help identify the drugs that might cause these reactions, making it safer for patients to receive the right treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 8, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $841,591 |
| NIH project number | 5R01AI181221-02 |
| Project ID | NIH-10983333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced drug hypersensitivity reactions or are at risk of such reactions.
✕Less likely to help
Patients who have not had any adverse reactions to medications or those without a history of drug allergies may not benefit from this research.
What this research studies
This research investigates delayed-type drug hypersensitivity reactions (dtDHR), which can cause severe skin reactions and other serious health issues. The study aims to identify the specific immune cells involved in these reactions and develop a reliable laboratory test to pinpoint the drugs responsible for these adverse effects. By analyzing the clonal repertoire of T cells in the skin, the researchers hope to create a method for screening patients before they receive certain medications, potentially preventing harmful reactions. This innovative approach combines advanced technologies with clinical insights to improve patient safety and care.
Why it matters
Potential benefit: If successful, this research could lead to better identification and prevention of severe drug allergies, improving patient safety and treatment outcomes.
How similar studies have gone: Previous research has shown promise in understanding immune responses related to drug allergies, but this specific approach of clonal repertoire analysis is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Divito, Sherrie Jill — Brigham and Women's Hospital
- Study coordinator: Divito, Sherrie Jill
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.