Understanding immune responses in chronic graft versus host disease after stem cell transplants
Single Cell Analysis and Immunogenetics
['FUNDING_P01'] · DANA-FARBER CANCER INST · NIH-10914134
This study is looking at how the immune system reacts to treatments for chronic graft versus host disease (cGVHD) after stem cell transplants, with the goal of finding better, personalized ways to help patients feel better.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10914134 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing how the immune system responds to treatments for chronic graft versus host disease (cGVHD) that can occur after hematopoietic stem cell transplantation. By using advanced techniques like single-cell and bulk transcriptome sequencing, the study aims to identify key pathways and immune responses involved in cGVHD and related conditions such as Bronchiolitis Obliterans Syndrome. The research will also explore genetic differences between donors and recipients to better understand treatment resistance and response. This comprehensive approach may lead to more personalized treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone hematopoietic stem cell transplantation and are experiencing chronic graft versus host disease.
Not a fit: Patients who have not undergone stem cell transplantation or do not have chronic graft versus host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients suffering from chronic graft versus host disease.
How similar studies have performed: Other research has shown promise in using single-cell analysis and immunogenetics to understand immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIVAK, KENNETH JAMES — DANA-FARBER CANCER INST
- Study coordinator: LIVAK, KENNETH JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.