Understanding immune responses in Chagas disease
Immunoregulation of cellular immunity and tissue homeostasis during Chagas' disease
This study looks at how the immune system fights Chagas disease and focuses on a type of immune cell called CD8+ T cells, hoping to find ways to improve treatments for patients by understanding how these cells work and what challenges they face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Research Council of Argentina NIH-funded |
| Lab location | 1 site (Cordoba, Argentina) |
| Project ID | NIH-11075320 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to Chagas disease, which is caused by the parasite Trypanosoma cruzi. It focuses on the role of CD8+ T cells, which are crucial for fighting the infection, and how their effectiveness can be influenced by various immune regulatory mechanisms. By exploring the metabolic challenges faced by these immune cells and the interactions between different immune pathways, the research aims to uncover insights that could lead to better treatments for Chagas disease. Patients may benefit from a deeper understanding of their immune responses and potential new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chagas disease, particularly those experiencing chronic symptoms.
Not a fit: Patients who do not have Chagas disease or are in the acute phase without chronic symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients suffering from Chagas disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses in similar infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Cordoba, Argentina
- National Research Council of Argentina — Cordoba, Argentina (Active)
Researchers
- Principal investigator: Acosta Rodriguez, Eva V — National Research Council of Argentina
- Study coordinator: Acosta Rodriguez, Eva V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.