Understanding immune responses in Chagas disease
Official title: Immunoregulation of cellular immunity and tissue homeostasis during Chagas' disease
Funded at National Research Council of Argentina · NIH-11075320 · Data updated 2026-11-12
This study looks at how the immune system fights Chagas disease and focuses on a type of immune cell called CD8+ T cells, hoping to find ways to improve treatments for patients by understanding how these cells work and what challenges they face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Research Council of Argentina NIH-funded |
| Lab location | 1 site (Cordoba, Argentina) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $133,800 |
| NIH project number | 5R01AI169482-04 |
| Project ID | NIH-11075320 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chagas disease, particularly those experiencing chronic symptoms.
✕Less likely to help
Patients who do not have Chagas disease or are in the acute phase without chronic symptoms may not benefit from this research.
What this research studies
This research investigates how the immune system responds to Chagas disease, which is caused by the parasite Trypanosoma cruzi. It focuses on the role of CD8+ T cells, which are crucial for fighting the infection, and how their effectiveness can be influenced by various immune regulatory mechanisms. By exploring the metabolic challenges faced by these immune cells and the interactions between different immune pathways, the research aims to uncover insights that could lead to better treatments for Chagas disease. Patients may benefit from a deeper understanding of their immune responses and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients suffering from Chagas disease.
How similar studies have gone: Previous research has shown promise in understanding immune responses in similar infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Research Council of Argentina
Cordoba, Argentina Active
Researchers
- Principal investigator: Acosta Rodriguez, Eva V — National Research Council of Argentina
- Study coordinator: Acosta Rodriguez, Eva V
Related research
Other NIH-funded projects on the same topics.
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Antibody-boosted immune responses in Chagas disease
A study in people with Chagas disease examines how antibody-producing B cells influence infection and disease outcome.
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How the immune system protects tissues during Chagas disease
This work explores how key immune cells fight the Trypanosoma cruzi parasite and help keep organs healthy in people with Chagas disease.
-
Blocking signals that help the Chagas parasite survive in the heart
This project looks at whether stopping the signals that turn injury-related ATP into immune-suppressing adenosine could help people with Chagas-related heart disease.
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Investigating how purinergic signaling affects Chagas disease
This study is looking at how the immune system and inflammation affect Chagas disease, especially how certain molecules might influence heart problems in patients, with the goal of finding new ways to help improve treatment for those dealing with this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.