Understanding immune responses in anal cancer linked to HPV.
Characterisation and harnessing the CD8+ Tissue Resident Memory T cell response in HPV-driven anal neoplasia.
This study is looking at how certain immune cells in the body help protect against precancerous changes in the anal area caused by high-risk HPV, especially in people living with HIV, and it needs tissue samples and health information from patients to better understand how to prevent these changes from turning into anal cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New South Wales NIH-funded |
| Lab location | 1 site (Sydney, Australia) |
| Project ID | NIH-10435548 on NIH RePORTER |
What this research studies
This research investigates how specific immune cells, known as CD8+ tissue resident memory T cells, respond to precancerous lesions in the anal region caused by high-risk human papillomavirus (HPV). By analyzing tissue samples from HIV-infected individuals, the study aims to uncover the mechanisms that prevent the progression of these lesions to anal cancer. The research utilizes existing clinical data and tissue archives from a previous study, focusing on the role of these immune cells in controlling disease progression. Patients may be involved in providing tissue samples and clinical information to help advance our understanding of anal cancer immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include HIV-infected adults who have been diagnosed with high-grade squamous intraepithelial lesions (HSIL) related to HPV.
Not a fit: Patients who do not have HPV-related anal lesions or are not HIV-infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against anal cancer, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in HPV-related cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
Sydney, Australia
- University of New South Wales — Sydney, Australia (Active)
Researchers
- Principal investigator: Kelleher, Anthony — University of New South Wales
- Study coordinator: Kelleher, Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.