Understanding immune responses and treatment effects in lung infections caused by Mycobacterium avium complex.
Mycobacterium avium complex pulmonary infection: immunologic and transcriptomic signatures of disease and treatment response
This study is looking at how your immune system reacts to infections from Mycobacterium avium complex (MAC) and how those reactions can help us understand how well treatments are working, so we can find better ways to help people with this lung disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10804153 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds to infections caused by Mycobacterium avium complex (MAC) and how these responses relate to treatment outcomes. By analyzing blood samples and other biological markers, the study aims to identify specific signatures that indicate disease severity and treatment effectiveness. Patients will be monitored over time to assess their response to a combination of antibiotics, which are typically required for extended periods. The goal is to improve diagnostic methods and treatment strategies for individuals suffering from this chronic lung disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with underlying lung conditions who have been diagnosed with MAC pulmonary disease.
Not a fit: Patients who do not have MAC pulmonary disease or those who are not experiencing significant symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with MAC pulmonary infections.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for other pulmonary infections, suggesting that this approach may yield valuable insights for MAC as well.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Winthrop, Kevin Loring — Oregon Health & Science University
- Study coordinator: Winthrop, Kevin Loring
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.