Understanding immune responses and outcomes in acute pancreatitis
Official title: Immune Signatures and Clinical Outcomes in Acute Pancreatitis
Funded at Ohio State University · NIH-11083575 · Data updated 2026-11-12
This study is looking at how certain markers in the blood can help doctors predict which patients with acute pancreatitis might have a more severe illness, so they can provide better early treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 4, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $680,769 |
| NIH project number | 5R01DK134698-03 |
| Project ID | NIH-11083575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals admitted to the hospital with acute pancreatitis, particularly those at risk of developing severe disease.
✕Less likely to help
Patients with mild acute pancreatitis who are not at risk for severe complications may not benefit from this research.
What this research studies
This research investigates how immune signatures can predict clinical outcomes in patients with acute pancreatitis (AP). By analyzing blood samples from patients, the study aims to identify specific cytokine profiles that can indicate which patients are likely to develop severe forms of the disease. The approach involves a multi-center, observational cohort design, allowing for a diverse patient population and robust data collection. The ultimate goal is to improve early prediction and treatment strategies for patients suffering from acute pancreatitis.
Why it matters
Potential benefit: If successful, this research could lead to better prediction tools and targeted therapies for patients with acute pancreatitis, potentially reducing hospital stays and improving survival rates.
How similar studies have gone: Previous research has shown promise in using immune signatures for predicting outcomes in other conditions, suggesting that this approach may also be effective in acute pancreatitis.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Papachristou, Georgios I — Ohio State University
- Study coordinator: Papachristou, Georgios I
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
-
Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.