Understanding immune responses after cardiac arrest
Protective adaptive immune mechanisms after cardiac arrest
This study is looking at how the immune system helps the heart and brain heal after a cardiac arrest, especially focusing on certain immune cells that might reduce inflammation and improve recovery, with the goal of finding new treatments for people who have gone through this experience.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11064814 on NIH RePORTER |
What this research studies
This research investigates how the immune system responds after a cardiac arrest, focusing on protective mechanisms that may help reduce inflammation and improve recovery. It aims to explore the role of specific immune cells, particularly CD73-expressing lymphocytes, in controlling inflammation in the heart and brain following cardiac arrest. The study will utilize both human patient data and mouse models to assess the effectiveness of adoptive cell therapy and the formation of immune cell complexes that promote healing. By understanding these processes, the research seeks to identify new therapeutic strategies for patients who have experienced cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a cardiac arrest and are undergoing recovery.
Not a fit: Patients who have not experienced cardiac arrest or have other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and improve outcomes for patients who suffer from cardiac arrest.
How similar studies have performed: Other research has shown promising results in using immune modulation to improve outcomes after cardiac events, suggesting that this approach may be effective.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Ryzhov, Sergey — Mainehealth
- Study coordinator: Ryzhov, Sergey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.