Understanding immune responses after cardiac arrest
Official title: Protective adaptive immune mechanisms after cardiac arrest
Funded at Mainehealth · NIH-11064814 · Data updated 2026-11-12
This study is looking at how the immune system helps the heart and brain heal after a cardiac arrest, especially focusing on certain immune cells that might reduce inflammation and improve recovery, with the goal of finding new treatments for people who have gone through this experience.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 2, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $579,700 |
| NIH project number | 5R01HL173118-02 |
| Project ID | NIH-11064814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a cardiac arrest and are undergoing recovery.
✕Less likely to help
Patients who have not experienced cardiac arrest or have other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates how the immune system responds after a cardiac arrest, focusing on protective mechanisms that may help reduce inflammation and improve recovery. It aims to explore the role of specific immune cells, particularly CD73-expressing lymphocytes, in controlling inflammation in the heart and brain following cardiac arrest. The study will utilize both human patient data and mouse models to assess the effectiveness of adoptive cell therapy and the formation of immune cell complexes that promote healing. By understanding these processes, the research seeks to identify new therapeutic strategies for patients who have experienced cardiac arrest.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and improve outcomes for patients who suffer from cardiac arrest.
How similar studies have gone: Other research has shown promising results in using immune modulation to improve outcomes after cardiac events, suggesting that this approach may be effective.
Where this research is happening
-
Mainehealth
Portland, United States Active
Researchers
- Principal investigator: Ryzhov, Sergey — Mainehealth
- Study coordinator: Ryzhov, Sergey
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
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Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
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Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.