Understanding immune response during sepsis
Official title: Modulation of innate immune exhaustion during sepsis
Funded at Virginia Polytechnic Inst and St Univ · NIH-11010874 · Data updated 2026-11-12
This study is looking at how the immune system gets tired during sepsis, a serious condition, to find out more about the immune cells involved, with the hope of discovering better treatments that can help patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | February 13, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $527,487 |
| NIH project number | 5R01AI172133-03 |
| Project ID | NIH-11010874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sepsis or at high risk of developing sepsis.
✕Less likely to help
Patients with non-infectious conditions or those not experiencing sepsis may not benefit from this research.
What this research studies
This research investigates how the immune system becomes exhausted during sepsis, a severe condition that can lead to organ failure. By combining experimental and computational methods, including advanced single-cell RNA sequencing, the study aims to identify the characteristics of immune cells that are both suppressive and inflammatory in sepsis patients. The goal is to develop new strategies to modulate these immune responses to improve patient outcomes. Patients may benefit from insights that could lead to more effective treatments for sepsis.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for sepsis, potentially reducing organ damage and enhancing recovery.
How similar studies have gone: Previous research has shown promise in understanding immune responses in sepsis, but this approach is exploring novel mechanisms that have not been extensively tested.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Li, Liwu — Virginia Polytechnic Inst and St Univ
- Study coordinator: Li, Liwu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.