Understanding immune response changes after cardiac arrest
Immunosuppression after cardiac arrest and resuscitation
This study looks at how the immune system reacts after someone has a cardiac arrest and is brought back to life, with the goal of finding ways to help them recover better and avoid infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10994149 on NIH RePORTER |
What this research studies
This research investigates how the immune system changes after a patient experiences cardiac arrest and is resuscitated. It focuses on the shift from an initial inflammatory response to a later state of immunosuppression, which can lead to infections and poor recovery. By using a mouse model that mimics human cardiac arrest scenarios, the researchers aim to uncover the underlying mechanisms of this immune response and explore potential treatments to improve outcomes for patients. The findings could help develop new therapies to enhance recovery in cardiac arrest survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a cardiac arrest and are recovering in an intensive care unit.
Not a fit: Patients who have not experienced cardiac arrest or those with terminal illnesses unrelated to cardiac events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients who survive cardiac arrest.
How similar studies have performed: Other research has shown promising results in understanding immune responses in critical care settings, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Yang, Wei — Duke University
- Study coordinator: Yang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.