Understanding immune problems after trauma and surgical infections
Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis
This study is looking at how trauma and severe infections affect the immune system, especially in people who get really sick, to understand why some patients recover quickly while others struggle, with the hope of finding better treatments to help everyone heal faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11116901 on NIH RePORTER |
What this research studies
This research investigates how trauma and surgical sepsis affect the immune system, leading to critical illness. It aims to identify the differences in immune responses between patients who recover quickly and those who experience prolonged illness or death. By utilizing advanced techniques like single cell multiomics and blood analysis, the study seeks to uncover the underlying mechanisms of immune dysfunction and its impact on patient outcomes. The findings could help in developing targeted therapies to improve recovery in critically ill patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced severe trauma or surgical sepsis and are at risk of developing critical illness.
Not a fit: Patients with mild injuries or those who do not experience significant immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from immune dysfunction after trauma or surgical sepsis.
How similar studies have performed: Previous research has shown promising results using similar multiomics approaches to study immune responses, indicating potential for success in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Billiar, Timothy R — University of Pittsburgh at Pittsburgh
- Study coordinator: Billiar, Timothy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.