Understanding Immune Problems After Severe Burn Injury
Elucidating the Mechanisms of Immune Dysfunction After Severe Burn Injury
['FUNDING_OTHER'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-11121860
This work aims to understand why children's immune systems sometimes struggle after a severe burn, leading to infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-11121860 on ClinicalTrials.gov |
What this research studies
When children experience severe burns, their immune system can become unbalanced, making them more vulnerable to serious infections. We are looking closely at how the body's immune cells and responses change after a burn, both in the blood and in affected tissues. Our goal is to find specific signs, called biomarkers, that can tell us which children are most at risk for these infections. By understanding these changes, we hope to develop better ways to prevent and treat these complications, ultimately improving recovery for young burn patients.
Who could benefit from this research
Good fit: This research is relevant to children who have experienced severe thermal burn injuries and are at risk for immune complications.
Not a fit: Patients with minor burns or those without immune system complications from their injury may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify children at high risk for infection after burns and develop new treatments to boost their immune system and improve their recovery.
How similar studies have performed: While the link between burn injury and immune changes is known, the exact underlying mechanisms driving these dysfunctional responses are still largely unknown, making this a novel area of focus.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THAKKAR, RAJAN — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: THAKKAR, RAJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.