Understanding immune issues in Down syndrome using advanced organ models
Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip System
This study is looking at how the extra chromosome 21 in people with Down syndrome affects their immune system and lung health, using a special technology to mimic lung tissues and immune cells, so we can learn more about why they might get respiratory infections more easily and find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11041683 on NIH RePORTER |
What this research studies
This research investigates how the extra genetic material from chromosome 21 in individuals with Down syndrome affects their immune system, particularly in relation to lung health. By using innovative organ-on-a-chip technology, the study aims to replicate the complex interactions of lung tissues and immune cells to better understand the immune dysregulation and heightened susceptibility to respiratory infections seen in these patients. The approach allows for real-time observation of immune responses in a controlled environment, which could lead to new insights into treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome who experience recurrent respiratory infections.
Not a fit: Patients without Down syndrome or those who do not have respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of respiratory infections in individuals with Down syndrome.
How similar studies have performed: Previous research using organ-on-a-chip technology has shown promise in understanding various diseases, indicating potential for success in this novel application.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Hajipouran Benam, Kambez — University of Pittsburgh at Pittsburgh
- Study coordinator: Hajipouran Benam, Kambez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.