Understanding immune interactions in premature infants with intestinal issues
Official title: Epithelial-immune interactions in neonates with Spontaneous Intestinal Perforation
Funded at Yale University · NIH-11017048 · Data updated 2026-11-12
This study is looking at how certain cells in the intestines of premature babies, especially those with very low birth weight, work together, to help find better ways to spot and treat a serious condition called spontaneous intestinal perforation (SIP).
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $167,284 |
| NIH project number | 5K08DK133687-02 |
| Project ID | NIH-11017048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are extremely low birth weight infants, particularly those born prematurely and diagnosed with spontaneous intestinal perforation.
✕Less likely to help
Patients who are not premature or do not have spontaneous intestinal perforation may not benefit from this research.
What this research studies
This research investigates spontaneous intestinal perforation (SIP), a serious condition affecting premature infants, particularly those with very low birth weight. The study aims to understand how immune cells and epithelial cells interact in the intestines of these infants, as current knowledge about the causes and progression of SIP is limited. By analyzing the differences in immune cell types and their functions in affected infants compared to healthy controls, the researchers hope to identify potential biomarkers for early detection and develop targeted therapies. This work could lead to improved outcomes for infants at risk of this life-threatening condition.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for premature infants suffering from spontaneous intestinal perforation.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in similar conditions, but this specific approach to SIP is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Olaloye, Oluwabunmi — Yale University
- Study coordinator: Olaloye, Oluwabunmi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.