Understanding immune interactions in neuroendocrine tumors for better treatment options
Official title: Delineating the myeloid-centric immunosuppressive crosstalk as targets for prognosis and therapy in neuroendocrine tumors
Funded at Boston Medical Center · NIH-11004262 · Data updated 2026-11-12
This study is looking at how immune cells interact with neuroendocrine tumors to find new ways to predict outcomes and improve treatments, which could help patients get better care based on the results.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $246,752 |
| NIH project number | 5R21CA286402-02 |
| Project ID | NIH-11004262 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neuroendocrine tumors, particularly those experiencing varied disease progression and treatment responses.
✕Less likely to help
Patients with other types of cancers or those without neuroendocrine tumors may not receive any benefit from this research.
What this research studies
This research investigates the complex interactions between immune cells and neuroendocrine tumors (NETs) to identify new prognostic markers and therapeutic targets. By analyzing the tumor microenvironment and the role of tumor-associated macrophages, the study aims to uncover how these immune cells influence disease progression and treatment response. The approach involves advanced techniques like single-cell transcriptomic profiling to gain insights into the unique characteristics of these tumors. Patients may benefit from improved diagnostic tools and targeted therapies based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to more accurate prognostic markers and personalized treatment strategies for patients with neuroendocrine tumors.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in various cancers, suggesting that this approach could yield valuable insights for neuroendocrine tumors as well.
Where this research is happening
-
Boston Medical Center
Boston, United States Active
Researchers
- Principal investigator: Heaphy, Christopher M — Boston Medical Center
- Study coordinator: Heaphy, Christopher M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.