Understanding immune interactions in a type of dementia
Role of central and peripheral immune crosstalk in FTD-Grn neurodegeneration
This study is looking at how communication between the brain and the immune system affects brain health in younger people with frontotemporal dementia caused by progranulin mutations, using special lab-grown cells to better understand the disease and find new ways to help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10514263 on NIH RePORTER |
What this research studies
This research investigates how immune signaling between the brain and the body contributes to neurodegeneration in frontotemporal dementia with progranulin mutations, a form of Alzheimer's-related dementia that primarily affects younger individuals. The study will utilize human-derived stem cells to create models that mimic the disease, allowing researchers to explore the role of immune cells in brain health and disease progression. By examining the interactions between different types of immune cells and neurons, the research aims to uncover new insights into the mechanisms driving this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with frontotemporal dementia related to progranulin mutations, particularly those under 60 years of age.
Not a fit: Patients with other forms of dementia not related to progranulin mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target immune dysfunction in dementia, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding immune interactions in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Tansey, Maria de Lourdes Gamez — University of Florida
- Study coordinator: Tansey, Maria de Lourdes Gamez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.