Understanding immune changes in organ transplantation
Official title: Mechanistic and Bioinformatics Core
Funded at Icahn School of Medicine at Mount Sinai · NIH-11064092 · Data updated 2026-11-12
This study is looking at how our immune system can be trained to better handle organ transplants, and it's for patients who want to learn more about how to improve their treatment and outcomes after receiving a transplant.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $347,979 |
| NIH project number | 5P01AI168258-03 |
| Project ID | NIH-11064092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing or considering organ transplantation.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with unrelated immune disorders may not benefit from this research.
What this research studies
This research focuses on trained immunity, which involves significant changes in immune cell behavior and gene expression related to organ transplantation. The team at Mount Sinai, led by Dr. Jordi Ochando, will conduct in-depth studies to profile immune cells and validate potential therapeutic targets. They will also manage data and bioinformatics analyses to ensure accurate implementation of their findings. Patients may benefit from improved understanding and treatment strategies related to immune responses in transplantation.
Why it matters
Potential benefit: If successful, this research could lead to better management of immune responses in organ transplant patients, potentially improving transplant outcomes.
How similar studies have gone: Previous research on trained immunity has shown promise in improving transplant outcomes, indicating that this approach may be effective.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Ochando, Jordi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ochando, Jordi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.