Understanding immune changes during pregnancy and their impact on vaccination
Research Project 2 The pregnancy AdaptOME
['FUNDING_OTHER'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-11058442
This study looks at how a pregnant woman's immune system reacts to vaccines for respiratory viruses, like COVID-19, to see how it changes during pregnancy and how that might help protect both mom and baby.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11058442 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system changes throughout pregnancy, particularly in response to vaccinations against respiratory viruses like SARS-CoV-2. It aims to understand the balance between inflammation and tolerance that occurs as the body adapts to support the developing fetus. By studying these immune dynamics, the research seeks to uncover how they affect the effectiveness of vaccines and the transfer of antibodies to infants. This could provide insights into improving vaccination strategies for pregnant women.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women, particularly those who are receiving or considering vaccination against COVID-19.
Not a fit: Patients who are not pregnant or those who have already completed their pregnancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better vaccination protocols for pregnant women, enhancing both maternal and infant health.
How similar studies have performed: Other research has shown promising results in understanding immune responses during pregnancy, but this specific approach to comparing different vaccine platforms is relatively novel.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JUELG, BORIS DOMINIK — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: JUELG, BORIS DOMINIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.