Understanding immune cells in the human uterus after transplants
Official title: Project 2: Genesis and dynamics of human endometrial resident memory T cells revealed by uterus transplant recipients
Funded at University of Alabama at Birmingham · NIH-11075881 · Data updated 2026-11-12
This study is looking at special immune cells in the uterus of women who have had a uterus transplant to see how they work differently from those in the blood and lymph nodes, which could help us understand and improve treatments for uterine health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,362 |
| NIH project number | 5U19AI181105-02 |
| Project ID | NIH-11075881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women who have undergone uterus transplants and those with specific reproductive health concerns.
✕Less likely to help
Patients who do not have a uterus or are not experiencing reproductive health issues may not benefit from this research.
What this research studies
This research investigates the behavior and characteristics of resident memory T cells in the human endometrium, particularly in uterus transplant recipients. By examining these immune cells, the study aims to uncover how they differ from T cells found in blood and lymph nodes, which are typically less experienced. The research utilizes advanced sequencing techniques to analyze the endometrial tissue of both healthy individuals and transplant recipients, providing insights into how these immune cells contribute to tissue health and disease. This knowledge could lead to improved treatments for various conditions affecting the uterus and overall reproductive health.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses in the uterus, potentially leading to better treatments for reproductive health issues.
How similar studies have gone: While research on tissue resident memory T cells is ongoing, this specific focus on the human endometrium in the context of uterus transplants is relatively novel.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Porrett, Paige M — University of Alabama at Birmingham
- Study coordinator: Porrett, Paige M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.