Understanding Immune Cells in Heart Disease
Neutrophil lineage in inflammation
This research explores how specific immune cells called neutrophils contribute to inflammation and the development of heart and blood vessel diseases.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11187023 on NIH RePORTER |
What this research studies
Our bodies rely on immune cells called neutrophils to fight infections, but sometimes these cells can become overactive and cause damage to tissues. This project aims to uncover the precise ways neutrophils contribute to serious conditions like atherosclerosis and coronary artery disease, which are major causes of death worldwide. We want to understand how the body controls the number and activity of these cells, and how different types of neutrophils might drive the progression of heart disease. By learning more about these processes, we hope to identify new strategies to protect the heart and blood vessels from inflammatory damage.
Who could benefit from this research
Good fit: Patients with or at risk for inflammatory cardiovascular diseases like atherosclerosis and coronary artery disease, who are at least 21 years old, might eventually benefit from this research.
Not a fit: Patients whose health conditions are unrelated to neutrophil activity or inflammatory cardiovascular diseases may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent or treat cardiovascular diseases by targeting specific immune responses involving neutrophils.
How similar studies have performed: While the general role of inflammation in heart disease is recognized, this specific focus on neutrophil subsets and inflammasome activation in atherogenesis represents a novel area of investigation.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Catz, Sergio Daniel — Scripps Research Institute, the
- Study coordinator: Catz, Sergio Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.