Understanding Immune Cells in Eyelid Gland Problems Linked to Eye Surface Immune Conditions
Defining the Immune Cell Roles in Meibomian Gland Dysfunction in the Context of Ocular Surface Immune Diseases
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11127602
This research aims to understand how immune cells contribute to blockages in eyelid glands, especially for people with existing eye surface immune diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11127602 on ClinicalTrials.gov |
What this research studies
Many people experience meibomian gland dysfunction, a common issue where the eyelid glands that produce tear film lipids become blocked. This blockage often comes with inflammation on the eye's surface, and it can be even more severe for those with other immune-related eye conditions like allergies or Sjogren's syndrome. Since there are currently no specific medications for this problem, this work seeks to uncover the exact immune processes involved. By understanding these mechanisms, we hope to find new ways to help patients with these challenging eye conditions.
Who could benefit from this research
Good fit: This research is relevant for patients experiencing meibomian gland dysfunction, especially those who also have ocular surface immune diseases such as allergies, Sjogren's syndrome, or cicatricial pemphigoid.
Not a fit: Patients whose meibomian gland dysfunction is not linked to underlying ocular surface immune diseases may not directly benefit from the specific findings of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for meibomian gland dysfunction, particularly for patients whose condition is worsened by other immune diseases affecting the eye surface.
How similar studies have performed: Previous work by this team has shown a direct role for neutrophils in meibomian gland dysfunction in an allergic eye disease model, suggesting a promising direction for this current investigation.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SABAN, DANIEL RAPHAEL — DUKE UNIVERSITY
- Study coordinator: SABAN, DANIEL RAPHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.