Understanding Immune Cells and Genetics in Pulmonary Artery Hypertension
BMPR2, Monocytes and Macrophages in Pulmonary Artery Hypertension
This project explores how specific immune cells called monocytes and macrophages might cause the blood vessel damage seen in pulmonary arterial hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11192234 on NIH RePORTER |
What this research studies
We are looking into how immune cells called monocytes and macrophages contribute to pulmonary arterial hypertension (PAH), a serious lung condition. Our work focuses on a gene called BMPR2, which is often changed in PAH, and how it might affect these immune cells. We are also exploring how a specific viral element and other genetic factors within these cells could lead to inflammation and damage in the lung's blood vessels. By understanding these complex interactions, we hope to uncover new ways to stop the progression of PAH.
Who could benefit from this research
Good fit: This research is most relevant to individuals living with pulmonary arterial hypertension, particularly women, as it seeks to understand the underlying cellular changes in their condition.
Not a fit: Patients not diagnosed with pulmonary arterial hypertension would not directly benefit from the findings of this specific research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for medications to prevent or reverse the damaging changes in blood vessels for people with pulmonary arterial hypertension.
How similar studies have performed: This project builds upon existing knowledge about immune cells and genetic factors in PAH, extending previous findings with novel connections.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Rabinovitch, Marlene — Stanford University
- Study coordinator: Rabinovitch, Marlene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.