Understanding Immune Cell Interactions in Multiple Sclerosis
Pathogenic B cell:CD4 T cell interactions in a novel B cell-dependent EAE mouse model of multiple sclerosis
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11124119
This research explores how specific immune cells called B cells interact with other immune cells to drive multiple sclerosis, aiming to uncover new treatment possibilities.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11124119 on ClinicalTrials.gov |
What this research studies
Multiple sclerosis (MS) is a challenging disease where the immune system attacks the brain and spinal cord. While current treatments help manage symptoms, the disease often progresses. We know that therapies targeting B cells, a type of immune cell, have been successful, but we need to understand exactly how B cells contribute to MS beyond just making antibodies. This project uses a new mouse model of MS that specifically relies on B cells to understand their role in supporting other immune cells called CD4 T cells. By studying these interactions, we hope to identify new ways to stop the disease progression.
Who could benefit from this research
Good fit: This foundational research is relevant for patients living with multiple sclerosis who may benefit from future, more targeted treatment options.
Not a fit: Patients looking for immediate clinical trial participation or direct treatment will not find that in this basic science animal model research.
Why it matters
Potential benefit: Success in this research could lead to the development of new, more effective therapies for multiple sclerosis by targeting the specific ways B cells contribute to the disease.
How similar studies have performed: While B cell-targeting therapies are already used for MS, this specific animal model and the detailed investigation into B cell-T cell interactions represent a novel approach to understanding the disease.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOYDEN, ALEXANDER — UNIVERSITY OF IOWA
- Study coordinator: BOYDEN, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.