Understanding Immune Cell Interactions in Lupus and Blood Clots
Project 3- Role of Leukocyte-Platelet Interactions in Inflammation and Thrombosis
['FUNDING_P01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11124009
This project explores how certain immune cells and blood components interact in lupus to cause inflammation and blood clots, aiming to find new ways to help patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11124009 on ClinicalTrials.gov |
What this research studies
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many women, particularly those of African American and Hispanic descent. Patients with SLE often experience chronic pain, fatigue, and serious issues like cardiovascular disease and arthritis. This research looks closely at how specific immune cells, like neutrophils and monocytes, and blood platelets contribute to the inflammation and blood clot formation seen in SLE. By understanding these interactions better, we hope to develop more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for future related studies might be individuals diagnosed with systemic lupus erythematosus, especially women and those of African American or Hispanic heritage.
Not a fit: Patients without systemic lupus erythematosus would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, targeted treatments for systemic lupus erythematosus that address the root causes of inflammation and blood clots, improving patient outcomes.
How similar studies have performed: While there are new advances in understanding SLE, this project aims to address significant unmet clinical needs by exploring novel aspects of immune cell interactions.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMON, DANIEL I — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: SIMON, DANIEL I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arterial Injury