Understanding immune cell interactions in autoimmune diseases
Computational systems immunology core
This study is looking at how immune cells work together in the tissues of people with lupus and rheumatoid arthritis, using advanced techniques to better understand their roles and interactions, which could help improve treatments for these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064778 on NIH RePORTER |
What this research studies
This research focuses on using advanced genomic and imaging techniques to explore how immune cells interact in tissues affected by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By analyzing single-cell data, the research aims to identify key populations of immune cells, such as B and T lymphocytes, monocytes, and fibroblasts, and understand their roles in these autoimmune conditions. The project employs computational strategies to interpret complex data sets, which will help in defining the relationships between different cell types and their functions in disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or rheumatoid arthritis.
Not a fit: Patients with other autoimmune conditions not specifically related to SLE or RA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with autoimmune diseases.
How similar studies have performed: Previous research utilizing similar genomic and imaging approaches has shown promise in understanding immune responses in autoimmune diseases.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Raychaudhuri, Soumya — Brigham and Women's Hospital
- Study coordinator: Raychaudhuri, Soumya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.